Genome Sequence of Aedes aegypti , a Major Arbovirus Vector

• DOI: 10.1126/science.1138878
• Publication Date: 2007-05-18T17:13:09Z
• Authors: Vishvanath Nene; Jennifer R. Wortman; Daniel Lawson; Brian Haas; Chinnappa Kodira; Zhijian (Jake) Tu; Brendan Loftus; Zhiyong Xi; Karyn Megy; Manfred Grabherr; Quinghu Ren; Evgeny M. Zdobnov; Neil F. Lobo; Kathryn S. Campbell; Susan E. Brown; Maria F. Bonaldo; Jingsong Zhu; Steven P. Sinkins; David G. Hogenkamp; Paolo Amedeo; Peter Arensburger; Peter W. Atkinson; Shelby Bidwell; Jim Biedler; Ewan Birney; Robert V. Bruggner; Javier Costas; Monique R. Coy; Jonathan Crabtree; Matt Crawford; Becky deBruyn; David DeCaprio; Karin Eiglmeier; Eric Eisenstadt; Hamza El-Dorry; William M. Gelbart; Suely L. Gomes; Martin Hammond; Linda I. Hannick; James R. Hogan; Michael H. Holmes; David Jaffe; J. Spencer Johnston; Ryan C. Kennedy; Hean Koo; Saul Kravitz; Evgenia V. Kriven...; David Kulp; Kurt LaButti; Eduardo Lee; Song Li; Diane D. Lovin; Chunhong Mao; Evan Mauceli; Carlos F. M. Menck; Jason R. Miller; Philip Montgomery; Akio Mori; Ana L. Nascimento; Horacio F. Naveira; Chad Nusbaum; Sinéad O'Leary; Joshua Orvis; Mihaela Pertea; Hadi Quesneville; Kyanne R. Reidenbach; Yu-Hui Rogers; Charles W. Roth; Jennifer R. Schne...; Michael Schatz; Martin Shumway; Mario Stanke; Eric O. Stinson; Jose M. C. Tubio; Janice P. VanZee; Sergio Verjovski-...; Doreen Werner; Owen White; Stefan Wyder; Qiandong Zeng; Qi Zhao; Yongmei Zhao; Catherine A. Hill; Alexander S. Raikhel; Marcelo B. Soares; Dennis L. Knudson; Norman H. Lee; James Galagan; Steven L. Salzberg; Ian T. Paulsen; George Dimopoulos; Frank H. Collins; Bruce Birren; Claire M. Fraser-...; David W. Severson
• Keywords: Sequence (biology)

We present a draft sequence of the genome Aedes aegypti, primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times size malaria Anopheles gambiae. Nearly 50% Ae. aegypti consists transposable elements. These contribute to factor 4 6 increase in average gene length sizes intergenic regions relative An. gambiae Drosophila melanogaster. Nonetheless, chromosomal synteny generally maintained among all three insects, although conservation orthologous order higher (by 2) between mosquito species than either them fruit fly. An genes encoding odorant binding, cytochrome P450, cuticle domains suggests that members these protein families underpin some biological differences two species.