Evolutionary and Biomedical Insights from the Rhesus Macaque Genome

• DOI: 10.1126/science.1139247
• Publication Date: 2007-04-12T22:08:39Z
• Authors: Richard A. Gibbs; Jeffrey Rogers; Michael G. Katze; Roger Bumgarner; George M. Weinstock; Elaine R. Mardis; Karin A. Remington; Robert L. Strausberg; J. Craig Venter; Richard K. Wilson; Mark A. Batzer; Carlos D. Bustamante; Evan E. Eichler; Matthew W. Hahn; Ross C. Hardison; Kateryna D. Makova; Webb Miller; Aleksandar Milosa...; Robert E. Palermo; Adam Siepel; James M. Sikela; Tony Attaway; Stephanie Bell; Kelly E. Bernard; Christian J. Buhay; Mimi N. Chandrabose; Marvin Dao; Clay Davis; Kimberly D. Deleh...; Yan Ding; Huyen H. Dinh; Shannon Dugan-Rocha; Lucinda A. Fulton; Ramatu Ayiesha Ga...; Toni T. Garner; Jennifer Godfrey; Alicia C. Hawes; Judith Hernandez; Sandra Hines; Michael Holder; Jennifer Hume; Shalini N. Jhangiani; Vandita Joshi; Ziad Mohid Khan; Ewen F. Kirkness; Andrew Cree; R. Gerald Fowler; Sandra Lee; Lora R. Lewis; Zhangwan Li; Yih-shin Liu; Stephanie M. Moore; Donna Muzny; Lynne V. Nazareth; Dinh Ngoc Ngo; Geoffrey O. Okwuonu; Grace Pai; David Parker; Heidie A. Paul; Cynthia Pfannkoch; Craig S. Pohl; Yu-Hui Rogers; San Juana Ruiz; Aniko Sabo; Jireh Santibanez; Brian W. Schneider; Scott M. Smith; Erica Sodergren; Amanda F. Svatek; Teresa R. Utterback; Selina Vattathil; Wesley Warren; Courtney Sherell ...; Asif T. Chinwalla; Yucheng Feng; Aaron L. Halpern; LaDeana W. Hillier; Xiaoqiu Huang; Pat Minx; Joanne O. Nelson; Kymberlie H. Pepin; Xiang Qin; Granger G. Sutton; Eli Venter; Brian P. Walenz; John W. Wallis; Kim C. Worley; Shiaw-Pyng Yang; Steven M. Jones; Marco A. Marra; Mariano Rocchi; Jacqueline E. Schein; Robert Baertsch; Laura Clarke; Miklós Csürös; Jarret Glasscock; R. Alan Harris; Paul Havlak; Andrew R. Jackson; Huaiyang Jiang; Yue Liu; David N. Messina; Yufeng Shen; Henry Xing-Zhi Song; Todd Wylie; Lan Zhang; Ewan Birney; Kyudong Han; Miriam K. Konkel; Jungnam Lee; Arian F. A. Smit; Brygg Ullmer; Hui Wang; Jinchuan Xing; Richard Burhans; Ze Cheng; John E. Karro; Jian Ma; Brian Raney; Xinwei She; Michael J. Cox; Jeffery P. Demuth; Laura J. Dumas; Sang-Gook Han; Janet Hopkins; Anis Karimpour-Fard; Young H. Kim; Jonathan R. Pollack; Tomas Vinar; Charles Addo-Quaye; Jeremiah Degenhardt; Alexandra Denby; Melissa J. Hubisz; Amit Indap; Carolin Kosiol; Bruce T. Lahn; Heather A. Lawson; Alison Marklein; Rasmus Nielsen; Eric J. Vallender; Andrew G. Clark; Betsy Ferguson; Ryan D. Hernandez; Kashif Hirani; Hildegard Kehrer-...; Jessica Kolb; Shobha Patil; Ling-Ling Pu; Yanru Ren; David Glenn Smith; David A. Wheeler; Ian Schenck; Edward V. Ball; Rui Chen; David N. Cooper; Belinda Giardine; Fan Hsu; W. James Kent; Arthur Lesk; David L. Nelson; William E. O'Brien; Kay Prüfer; Peter D. Stenson; James C. Wallace; Hui Ke; Xiao-Ming Liu; Peng Wang; Andy Peng Xiang; Fan Yang; Galt P. Barber; David Haussler; Donna Karolchik; Andy D. Kern; Robert M. Kuhn; Kayla E. Smith; Ann S. Zwieg
• Keywords: Rhesus macaque; Homo sapiens; Non human primate; Lineage (genetic)

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and physiologically similar to humans, monkeys most widely used nonhuman in basic applied biomedical research. We determined genome sequence Indian-origin Macaca mulatta female compared data with chimpanzees humans reveal structure ancestral genomes identify evidence for positive selection lineage-specific expansions contractions gene families. A comparison sequences individual animals was investigate their underlying genetic diversity. complete description blueprint enhances utility this animal model research improves our understanding biology species.