Regulation of B Versus T Lymphoid Lineage Fate Decision by the Proto-Oncogene LRF

• DOI: 10.1126/science.1140881
• Publication Date: 2007-05-10T21:45:54Z
• Authors: Takahiro Maeda; Taha Merghoub; Robin M. Hobbs; Lin Dong; Manami Maeda; Johannes Zakrzewski; Marcel R.M. van d...; Arthur Zelent; Hirokazu Shigematsu; Koichi Akashi; Julie Teruya-Feld...; Giorgio Cattoretti; Pier Paolo Pandolfi
• Keywords: Lineage (genetic); Cell fate determination; Lymphopoiesis; Cell lineage

Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here we show that proto-oncogene LRF plays an essential role versus cell-fate decision. We demonstrate is key for instructing early progenitors mice develop lineage by repressing cell-instructive signals produced signal protein, Notch. propose a new model commitment, acts as master regulator of cell's determination lineage.