Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

• DOI: 10.1126/science.1142883
• Publication Date: 2007-08-02T21:08:01Z
• Authors: Cedric Auffray; Darin Fogg; Meriem Garfa; Gaelle Elain; Olivier Join-Lambert; Samer Kayal; Sabine Sarnacki; Ana Cumano; Gregoire Lauvau; Frederic Geissmann
• Keywords: Extravasation; Leukocyte extravasation; Monocyte; Patrolling; CCR2

The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on endothelium recognition inflammation followed by extravasation. We have shown, direct examination monocyte functions in vivo, that subset monocytes patrols healthy tissues long-range crawling resting endothelium. patrolling behavior depended integrin LFA-1 chemokine receptor CX(3)CR1 was required for rapid invasion at site an this "resident" population, initiated early differentiated into macrophages.