The Arabidopsis Circadian Clock Incorporates a cADPR-Based Feedback Loop

• DOI: 10.1126/science.1146757
• Publication Date: 2007-11-16T01:54:53Z
• Authors: Antony N. Dodd; Michael J. Gardner; Carlos T. Hotta; Katharine E. Hubbard; Neil Dalchau; John Love; Jean-Maurice Assie; Fiona C. Robertson; Mia Kyed Jakobsen; Jorge Gonçalves; Dale Sanders; Alex A. R. Webb
• Keywords: Feedback loop; Negative feedback; Positive feedback

Transcriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant clock also incorporates cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR). cADPR modulates oscillator's transcriptional drives oscillations Ca 2+ release. The effects antagonists signaling, manipulation synthesis, mathematical simulation interaction with indicate forms loop within clock.