Synaptic Protein Degradation Underlies Destabilization of Retrieved Fear Memory

• DOI: 10.1126/science.1150541
• Publication Date: 2008-02-08T02:36:47Z
• Authors: Sue-Hyun Lee; Jun-Hyeok Choi; Nuribalhae Lee; Hye-Ryeon Lee; Jae-Ick Kim; Nam-Kyung Yu; Sun-Lim Choi; Seung-Hee Lee; Hyoung Kim; Bong-Kiun Kaang
• Keywords: Anisomycin; Protein Degradation; Memory Impairment; Degradation; Extinction (optical mineralogy)

Reactivated memory undergoes a rebuilding process that depends on de novo protein synthesis. This suggests retrieval is dynamic and serves to incorporate new information into preexisting memories. However, little known about whether or not degradation involved in the reorganization of retrieved memory. We found postsynaptic proteins were degraded hippocampus by polyubiquitination after contextual fear Moreover, infusion proteasome inhibitor CA1 region immediately prevented anisomycin-induced impairment, as well extinction ubiquitin- proteasome-dependent underlies destabilization processes retrieval. It also provides strong evidence for existence whereby disrupted degradation, updated reconsolidated