Early Forebrain Wiring: Genetic Dissection Using Conditional Celsr3 Mutant Mice

• DOI: 10.1126/science.1155244
• Publication Date: 2008-05-16T03:08:31Z
• Authors: Libing Zhou; Isabelle Bar; Younès Achouri; Kenneth Campbell; Olivier De Backer; Jean M. Hebert; Kevin Jones; Nicoletta Kessaris; Catherine Lambert...; Dennis O'Leary; William D. Richar...; Andre M. Goffinet; Fadel Tissir
• Keywords: Forebrain; Commissure; Anterior commissure

Development of axonal tracts requires interactions between growth cones and the environment. Tracts such as anterior commissure internal capsule are defective in mice with null mutation Celsr3. We generated a conditional Celsr3 allele, allowing regional inactivation. Inactivation telencephalon, ventral forebrain, or cortex demonstrated essential roles for neurons that project axons to subcerebral targets, well cells guide through capsule. When was inactivated cortex, projections failed grow, yet corticothalamic developed normally, indicating besides guidepost cells, additional Celsr3-independent cues can assist their progression. These observations provide vivo evidence Celsr3-mediated govern tract formation mammals.