In Vivo Analysis of Dendritic Cell Development and Homeostasis

• DOI: 10.1126/science.1170540
• Publication Date: 2009-03-13T02:06:45Z
• Authors: Kang Liu; Gabriel D. Victora; Tanja A. Schwickert; Pierre Guermonprez; Matthew M. Meredith; Kaihui Yao; Fei-Fan Chu; Gwendalyn J. Rand...; Alexander Y. Rude...; Michel Nussenzweig
• Keywords: Precursor cell; Monocyte; Follicular dendritic cells; Homeostasis

Dendritic cells (DCs) in lymphoid tissue arise from precursors that also produce monocytes and plasmacytoid DCs (pDCs). Where DC monocyte lineage commitment occurs the nature of precursor migrates bone marrow to peripheral organs are unknown. We show development progresses macrophage common give rise pDCs classical spleen (cDCs), but not monocytes, finally committed cDCs (pre-cDCs). Pre-cDCs enter lymph nodes through migrate along high endothelial venules later disperse integrate into network. Further cDC involves cell division, which is controlled part by regulatory T fms-like tyrosine kinase receptor-3.