Dysregulated Humoral Immunity to Nontyphoidal Salmonella in HIV-Infected African Adults
Adult
Lipopolysaccharides
Salmonella typhimurium
Malawi
bactericidal activity
Bacteremia
HIV Infections
antibody titer
Mice
antibody
Keywords: bacterium antibody
Animals
Humans
membrane protein
bacteremia
Antibodies, Blocking
Complement Activation
Multidisciplinary
human immunodeficiency virus
AIDS-Related Opportunistic Infections
adult
lipopolysaccharide
antibody specificity
article
O Antigens
bacterium
immunity
Antibodies, Bacterial
3. Good health
cellular immuni
polysaccharide
1000 General
Immunoglobulin G
Mutation
Salmonella Infections
Disease Susceptibility
protein
serum
Bacterial Outer Membrane Proteins
DOI:
10.1126/science.1180346
Publication Date:
2010-04-22T18:59:11Z
AUTHORS (22)
ABSTRACT
HIV and
Salmonella
HIV-positive individuals who are infected with nontyphoidal strains of
Salmonella enterica
often succumb to high morbidity and mortality. Why this is the case is unknown.
MacLennan
et al.
(p.
508
; see the Perspective by
Moir and Fauci
) have uncovered a dysregulated antibody response to
Salmonella
that is the likely culprit. Sera from HIV-infected individuals do a poor job of killing
S.
Typhimurium, despite surprisingly elevated antibody titers. Experiments showed that HIV-infected serum inhibited the power of normal serum to kill
Salmonella
. Inhibition was specific to antibodies against lipopolysaccharide (LPS), a component of the cell wall of
Salmonella
. Hence, HIV-infected sera was able to kill
Salmonella
strains lacking LPS, and removing LPS immunoglobulin G from infected sera permitted
Salmonella
killing. Thus, not only does HIV cause defects in cell-mediated immunity but it also seems to impair humoral immunity, with severe consequences for multiple infections.
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