A Catalog of Reference Genomes from the Human Microbiome

• DOI: 10.1126/science.1183605
• Publication Date: 2010-05-20T13:35:12Z
• Authors: Karen E. Nelson; George M. Weinstock; Sarah K. Highlander; Kim C. Worley; Heather Huot Creasy; Jennifer Russo Wo...; Douglas B. Rusch; Makedonka Mitreva; Erica Sodergren; Asif T. Chinwalla; Michael Feldgarden; Dirk Gevers; Brian J. Haas; Ramana Madupu; Doyle V. Ward; Bruce W. Birren; Richard A. Gibbs; Barbara Methe; Joseph F. Petrosino; Robert L. Strausberg; Granger G. Sutton; Owen R. White; Richard K. Wilson; Scott Durkin; Michelle Gwinn Gi...; Sharvari Gujja; Clint Howarth; Chinnappa D. Kodira; Nikos Kyrpides; Teena Mehta; Donna M. Muzny; Matthew Pearson; Kymberlie Pepin; Amrita Pati; Xiang Qin; Chandri Yandava; Qiandong Zeng; Lan Zhang; Aaron M. Berlin; Lei Chen; Theresa A. Hepburn; Justin Johnson; Jamison McCorrison; Jason Miller; Pat Minx; Chad Nusbaum; Carsten Russ; Sean M. Sykes; Chad M. Tomlinson; Sarah Young; Wesley C. Warren; Jonathan Badger; Jonathan Crabtree; Victor M. Markowitz; Joshua Orvis; Andrew Cree; Steve Ferriera; Lucinda L. Fulton; Robert S. Fulton; Marcus Gillis; Lisa D. Hemphill; Vandita Joshi; Christie Kovar; Manolito Torralba; Kris A. Wetterstrand; Amr Abouellleil; Aye M. Wollam; Christian J. Buhay; Yan Ding; Shannon Dugan; Michael G. FitzGe...; Mike Holder; Jessica Hostetler; Sandra W. Clifton; Emma Allen-Vercoe; Ashlee M. Earl; Candace N. Farmer; Konstantinos Liolios; Michael G. Surette; Qiang Xu; Craig Pohl; Katarzyna Wilczek...; Dianhui Zhu
• Keywords: 0301 basic medicine; Mouth; Bacteria; Respiratory System; Computational Biology; Genetic Variation; Urogenital System; Biodiversity; Sequence Analysis, DNA; 3. Good health; Gastrointestinal Tract; 03 medical and health sciences; Bacterial Proteins; Genes, Bacterial; Genome, Archaeal; Databases, Genetic; Humans; Metagenome; Metagenomics; Peptides; Genome, Bacterial; Phylogeny; Skin

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A major initiative by the U.S. National Institutes of Health to sequence 900 genomes of microorganisms that live on the surfaces and orifices of the human body has established standardized protocols and methods for such large-scale reference sequencing. By combining previously accumulated data with new data,

Nelson et al.

(p. 994 ) present an initial analysis of 178 bacterial genomes. The sampling so far barely scratches the surface of the microbial diversity found on humans, but the work provides an important baseline for future analyses.