Noncanonical TGFβ Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

• DOI: 10.1126/science.1192149
• Publication Date: 2011-04-14T18:44:18Z
• Authors: Tammy M. Holm; Jennifer P. Habashi; Jefferson J. Doyle; Djahida Bedja; YiChun Chen; Christel van Erp; Mark E. Lindsay; David Kim; Florian Schoenhoff; Ronald D. Cohn; Bart L. Loeys; Craig J. Thomas; Samarjit Patnaik; Juan J. Marugan; Daniel P. Judge; Harry C. Dietz
• Keywords: Anthracenes; Mitogen-Activated Protein Kinase 1; 0301 basic medicine; Sulfonamides; Mitogen-Activated Protein Kinase 3; MAP Kinase Signaling System; Diphenylamine; Smad2 Protein; Losartan; Aortic Aneurysm; Marfan Syndrome; 3. Good health; Enzyme Activation; Disease Models, Animal; Mice; 03 medical and health sciences; IGMD 3: Genomic disorders and inherited multi-system disorders; Transforming Growth Factor beta; Disease Progression; Animals; Mitogen-Activated Protein Kinase 8; Protein Kinase Inhibitors; Aorta; Smad4 Protein

Transforming growth factor–β promotes aortic aneurysm formation through activation of its “noncanonical” signaling pathway.