Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

• DOI: 10.1126/science.1194637
• Publication Date: 2010-10-22T02:40:13Z
• Authors: Florent Ginhoux; Melanie Greter; Marylene Leboeuf; Sayan Nandi; Peter See; Solen Gokhan; Mark F. Mehler; Simon J. Conway; Lai Guan Ng; E. Richard Stanley; Igor M. Samokhvalov; Miriam Merad
• Keywords: Mononuclear phagocyte system; Fate mapping

Microglia are the resident macrophages of central nervous system and associated with pathogenesis many neurodegenerative brain inflammatory diseases; however, origin adult microglia remains controversial. We show that postnatal hematopoietic progenitors do not significantly contribute to homeostasis in brain. In contrast macrophage populations, we develop mice lack colony stimulating factor-1 (CSF-1) but absent CSF-1 receptor-deficient mice. vivo lineage tracing studies established derive from primitive myeloid arise before embryonic day 8. These results identify as an ontogenically distinct population mononuclear phagocyte have implications for use embryonically derived microglial treatment various disorders.