A Midzone-Based Ruler Adjusts Chromosome Compaction to Anaphase Spindle Length

• DOI: 10.1126/science.1201578
• Publication Date: 2011-03-11T03:50:33Z
• Authors: Gabriel Neurohr; Andreas Naegeli; Iris Titos; Dominik Theler; Basil Greber; Javier Díez; Toni Gabaldón; Manuel Mendoza; Yves Barral
• Keywords: 0301 basic medicine; Saccharomyces cerevisiae Proteins; Intracellular Signaling Peptides and Proteins; Saccharomyces cerevisiae; Spindle Apparatus; Protein Serine-Threonine Kinases; Histones; 03 medical and health sciences; Aurora Kinases; Chromosome Segregation; Mutation; Chromosomes, Fungal; Anaphase; Microtubule-Associated Proteins; Aldose-Ketose Isomerases

Partitioning of chromatids during mitosis requires that chromosome compaction and spindle length scale appropriately with each other. However, it is not clear whether condensation elongation are linked. Here, we find yeast cells could cope a 45% increase in the their longest arm by increasing its condensation. The midzone, aurora/Ipl1 activity, Ser10 histone H3 mediated this response. Thus, anaphase may function as ruler to adapt chromatids, promoting segregation regardless or length.