A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice
Blood Glucose
Light Signal Transduction
Light
NFATC Transcription Factors
Alkaline Phosphatase
GPI-Linked Proteins
Cell Line
Isoenzymes
Mice
Bioreactors
Diabetes Mellitus, Type 2
Gene Expression Regulation
Genes, Reporter
Glucagon-Like Peptide 1
Cell Line, Tumor
Animals
Homeostasis
Humans
Insulin
Genetic Engineering
DOI:
10.1126/science.1203535
Publication Date:
2011-06-25T11:40:35Z
AUTHORS (4)
ABSTRACT
An implanted device using blue-light–triggered expression of the glucagon-like peptide 1 attenuates diabetes in mice.
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