Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex

• DOI: 10.1126/science.1207125
• Publication Date: 2011-07-01T03:15:57Z
• Authors: Susanne Stefer; Simon Reitz; Fei Wang; Klemens Wild; Yin-Yuin Pang; Daniel Schwarz; Jörg Bomke; Christopher Hein; Frank Löhr; Frank Bernhard; Vladimir Denic; Volker Dötsch; Irmgard Sinning
• Keywords: Adenosine Triphosphatases; Models, Molecular; 0303 health sciences; Binding Sites; Molecular Sequence Data; Membrane Proteins; Crystallography, X-Ray; Endoplasmic Reticulum; Protein Structure, Secondary; Protein Structure, Tertiary; Adaptor Proteins, Vesicular Transport; Protein Subunits; 03 medical and health sciences; Adenosine Triphosphate; Cytosol; Catalytic Domain; Microsomes; Guanine Nucleotide Exchange Factors; Protein Interaction Domains and Motifs; Amino Acid Sequence; Protein Multimerization; Protein Binding

Docking of cytoplasmic and membrane receptors facilitates conformational changes that drive protein insertion.