BRCA1 Tumor Suppression Depends on BRCT Phosphoprotein Binding, But Not Its E3 Ligase Activity

• DOI: 10.1126/science.1209909
• Publication Date: 2011-10-27T18:57:18Z
• Authors: Reena Shakya; Latarsha J. Reid; Colleen R. Reczek; Francesca Cole; Dieter Egli; Chyuan-Sheng Lin; Dirk G. deRooij; Steffen Hirsch; Kandasamy Ravi; James B. Hicks; Matthias Szabolcs; Maria Jasin; Richard Baer; Thomas Ludwig
• Keywords: BRCA1 Protein; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases; Genes, BRCA1; Mammary Neoplasms, Experimental; Ligands; Phosphoproteins; 3. Good health; Pancreatic Neoplasms; Disease Models, Animal; Mice; Basic-Leucine Zipper Transcription Factors; Animals; Mutant Proteins; Protein Interaction Domains and Motifs; Protein Multimerization; RING Finger Domains; Cells, Cultured; Embryonic Stem Cells; Protein Binding

The properties of breast cancer susceptibility protein required for tumor suppression have been explored.