Sequential Signaling Crosstalk Regulates Endomesoderm Segregation in Sea Urchin Embryos

• DOI: 10.1126/science.1212867
• Publication Date: 2012-02-02T19:20:29Z
• Authors: Aditya J. Sethi; Radhika M. Wikram...; Robert C. Angerer; Ryan C. Range; Lynne M. Angerer
• Keywords: Crosstalk

The segregation of embryonic endomesoderm into separate endoderm and mesoderm fates is not well understood in deuterostomes. Using sea urchin embryos, we showed that Notch signaling initiates the precursor field by inhibiting expression a key transcription factor presumptive mesoderm. regulatory circuit activated this subsequently maintains canonical Wnt (cWnt) ligand only precursors. This cWnt reinforces state, amplifying distinction between emerging Before gastrulation, Notch-dependent nuclear export an essential β-catenin transcriptional coactivator from renders it refractory to signals, insulating against fate. Thus, report progressive process, requiring succession interactions signaling.