SAICAR Stimulates Pyruvate Kinase Isoform M2 and Promotes Cancer Cell Survival in Glucose-Limited Conditions

0301 basic medicine Cell Survival Pyruvate Kinase Fibroblasts Aminoimidazole Carboxamide Recombinant Proteins 3. Good health 03 medical and health sciences Glucose Allosteric Regulation Neoplasms Tumor Microenvironment Humans Ribonucleosides HeLa Cells
DOI: 10.1126/science.1224409 Publication Date: 2012-10-20T00:50:06Z
ABSTRACT
A metabolite is identified that may help cancer cells coordinate their mode of energy generation with nutrient conditions.
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