JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

• DOI: 10.1126/science.1227568
• Publication Date: 2012-12-07T06:41:31Z
• Authors: Myoung Sook Han; Dae Young Jung; Caroline Morel; Saquib A. Lakhani; Jason K. Kim; Richard A. Flavell; Roger J. Davis
• Keywords: Proinflammatory cytokine; Adipose tissue macrophages

Macrophage JNK in Metabolic Disease Inflammation is thought to be an important driver of diet-induced obesity and insulin resistance. Proinflammatory, M1 phenotype macrophages the c-jun NH 2 terminal kinases (JNK) are central players this process. But whether expression specifically required inside unclear. In mice containing a macrophage-specific deletion both Jnk1 Jnk2 , Han et al. (p. 218 published online 6 December; see Perspective by Ferrante Jr. ) found that were protected against many metabolic changes, including resistance, despite similar weight gain as control on high-fat diet. This protection was associated with decrease presence adipose tissue.