Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

Bridged-Ring Compounds 0301 basic medicine 1000 Multidisciplinary 0303 health sciences Binding Sites SX20 Research, Technology and Development Projects Antineoplastic Agents Crystallography, X-Ray Microtubules Protein Structure, Secondary Tubulin Modulators 3. Good health 03 medical and health sciences SX00 SystemsX.ch SX25 Bridge 2 Industry Projects Epothilones Tubulin 570 Life sciences; biology Animals Cattle Taxoids Macrolides Chickens
DOI: 10.1126/science.1230582 Publication Date: 2013-01-04T05:46:42Z
ABSTRACT
Dissecting Microtubule Stability Microtubule-stabilizing agents (MSAs), like taxol, inhibit cell division and are widely used in cancer chemotherapy. Prota et al. (p. 587 , published online 3 January) present structural data on the molecular mechanism of action of antimitotic drugs. Tubulin structures in complex with the MSAs zampanolide and epothilone A, revealed a general mechanism for how MSAs promote microtubule assembly and stability by affecting lateral tubulin interactions.
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