Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
Bridged-Ring Compounds
0301 basic medicine
1000 Multidisciplinary
0303 health sciences
Binding Sites
SX20 Research, Technology and Development Projects
Antineoplastic Agents
Crystallography, X-Ray
Microtubules
Protein Structure, Secondary
Tubulin Modulators
3. Good health
03 medical and health sciences
SX00 SystemsX.ch
SX25 Bridge 2 Industry Projects
Epothilones
Tubulin
570 Life sciences; biology
Animals
Cattle
Taxoids
Macrolides
Chickens
DOI:
10.1126/science.1230582
Publication Date:
2013-01-04T05:46:42Z
AUTHORS (7)
ABSTRACT
Dissecting Microtubule Stability
Microtubule-stabilizing agents (MSAs), like taxol, inhibit cell division and are widely used in cancer chemotherapy.
Prota
et al.
(p.
587
, published online 3 January) present structural data on the molecular mechanism of action of antimitotic drugs. Tubulin structures in complex with the MSAs zampanolide and epothilone A, revealed a general mechanism for how MSAs promote microtubule assembly and stability by affecting lateral tubulin interactions.
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