Genomic Analysis of Non- NF2 Meningiomas Reveals Mutations in TRAF7 , KLF4 , AKT1 , and SMO

KLF4 PDGFB
DOI: 10.1126/science.1233009 Publication Date: 2013-01-25T02:38:41Z
ABSTRACT
Genetic Clues to Meningioma Meningiomas are the most common primary brain tumors in adults. Located within layer of tissue covering brain, these usually slow-growing and benign but can cause serious neurological complications. About half have mutations neurofibromin 2 gene ( NF2 ). To identify other genes that contribute meningioma pathogenesis, Clark et al. (p. 1077 , published online 24 January) performed genome sequence analysis on 300 tumors. fell into two general classes: located at skull base—which tend harbor TRAF7, KLF4, AKT1 SMO genes—and higher-grade cerebral cerebellar hemispheres NF2.
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