Genomic Analysis of Non- NF2 Meningiomas Reveals Mutations in TRAF7 , KLF4 , AKT1 , and SMO

• DOI: 10.1126/science.1233009
• Publication Date: 2013-01-25T02:38:41Z
• Authors: Victoria E. Clark; E. Zeynep Erson-Omay; Akdes Serin; Jun Yin; Justin Cotney; Koray Özduman; Timuçin Avşar; Jie Li; Phillip B. Murray; Octavian Henegariu; Saliha Yilmaz; Jennifer Molitern...; Geneive Carrión-G...; Baran Yılmaz; Conor Grady; Bahattin Tanrıkulu; Mehmet Bakırcıoğlu; Hande Kaymakçalan; Ahmet Okay Caglayan; Leman Sencar; Emre Ceyhun; A. Fatih Atik; Yaşar Bayri; Hanwen Bai; Luis E. Kolb; Ryan M. Hebert; S. Bulent Omay; Ketu Mishra-Gorur; Murim Choi; John D. Overton; Eric C. Holland; Shrikant Mane; Matthew W. State; Kaya Bilgüvar; Joachim M. Baehring; Philip H. Gutin; Joseph M. Piepmeier; Alexander Vortmeyer; Cameron W. Brennan; M. Necmettin Pamir; Türker Kılıç; Richard P. Lifton; James P. Noonan; Katsuhito Yasuno; Murat Günel
• Keywords: Adult; Male; Neurofibromatosis 2; General Science & Technology; Chromosomes, Human, Pair 22; DNA Mutational Analysis; Kruppel-Like Transcription Factors; Chromosomes; Genomic Instability; G-Protein-Coupled; Kruppel-Like Factor 4; Rare Diseases; Genes, Neurofibromatosis 2; Receptors; Genetics; 80 and over; Meningeal Neoplasms; Humans; Cancer; Aged; Aged, 80 and over; Biomedical and Clinical Sciences; Brain Neoplasms; Human Genome; Neurosciences; Genomics; Biological Sciences; Middle Aged; Smoothened Receptor; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; Brain Disorders; 3. Good health; Brain Cancer; Genes; Mutation; Female; Pair 22; Neoplasm Grading; Meningioma; Proto-Oncogene Proteins c-akt; Human

Genetic Clues to Meningioma

Meningiomas are the most common primary brain tumors in adults. Located within the layer of tissue covering the brain, these tumors are usually slow-growing and benign but can cause serious neurological complications. About half of these tumors have mutations in the neurofibromin 2 gene ( NF2 ). To identify other genes that contribute to meningioma pathogenesis,

Clark et al.

(p. 1077 , published online 24 January) performed genome sequence analysis on 300 tumors. Meningiomas fell into two general classes: benign tumors located at the skull base—which tend to harbor mutations in the TRAF7, KLF4, AKT1 , and SMO genes—and higher-grade tumors located in the cerebral and cerebellar hemispheres harbor mutations in NF2.