Genomic Analysis of Non- NF2 Meningiomas Reveals Mutations in TRAF7 , KLF4 , AKT1 , and SMO

• DOI: 10.1126/science.1233009
• Publication Date: 2013-01-25T02:38:41Z
• Authors: Victoria E. Clark; E. Zeynep Erson-Omay; Akdes Serin; Jun Yin; Justin Cotney; Koray Özduman; Timuçin Avşar; Jie Li; Phillip B. Murray; Octavian Henegariu; Saliha Yilmaz; Jennifer Molitern...; Geneive Carrión-G...; Baran Yılmaz; Conor Grady; Bahattin Tanrıkulu; Mehmet Bakırcıoğlu; Hande Kaymakçalan; Ahmet Okay Caglayan; Leman Sencar; Emre Ceyhun; A. Fatih Atik; Yaşar Bayri; Hanwen Bai; Luis E. Kolb; Ryan M. Hebert; S. Bulent Omay; Ketu Mishra-Gorur; Murim Choi; John D. Overton; Eric C. Holland; Shrikant Mane; Matthew W. State; Kaya Bilgüvar; Joachim M. Baehring; Philip H. Gutin; Joseph M. Piepmeier; Alexander Vortmeyer; Cameron W. Brennan; M. Necmettin Pamir; Türker Kılıç; Richard P. Lifton; James P. Noonan; Katsuhito Yasuno; Murat Günel
• Keywords: KLF4; PDGFB

Genetic Clues to Meningioma Meningiomas are the most common primary brain tumors in adults. Located within layer of tissue covering brain, these usually slow-growing and benign but can cause serious neurological complications. About half have mutations neurofibromin 2 gene ( NF2 ). To identify other genes that contribute meningioma pathogenesis, Clark et al. (p. 1077 , published online 24 January) performed genome sequence analysis on 300 tumors. fell into two general classes: located at skull base—which tend harbor TRAF7, KLF4, AKT1 SMO genes—and higher-grade cerebral cerebellar hemispheres NF2.