Type I Interferon Suppresses Type II Interferon–Triggered Human Anti-Mycobacterial Responses

• DOI: 10.1126/science.1233665
• Publication Date: 2013-03-01T16:48:03Z
• Authors: Rosane M. B. Teles; Thomas G. Graeber; Stephan R. Krutzik; Dennis Montoya; Mirjam Schenk; Delphine J. Lee; Evangelia Komisop...; Kindra Kelly-Scumpia; Rene Chun; Shankar S. Iyer; Euzenir N. Sarno; Thomas H. Rea; Martin Hewison; John S. Adams; Stephen J. Popper; David A. Relman; Steffen Stenger; Barry R. Bloom; Genhong Cheng; Robert L. Modlin
• Keywords: Mycobacterium leprae

Interfering with Interferons Infections Mycobacteria, including Mycobacterium leprae or M. tuberculosis , vary substantially in their clinical presentation. For instance, some cases of the infection is self-healing very few lesions. In contrast, people experience disseminated form, where skin lesions abound and bacteria are abundant. patients infected Teles et al. (p. 1448 published online 28 February) found that disease associates a type I interferon gene signature, whereas form II signature. cultured cells, its downstream signaling cascade inhibited antimicrobial response induced by interferons, providing potential explanation for why robust rather than protection seen infection.