Global Epigenomic Reconfiguration During Mammalian Brain Development

• DOI: 10.1126/science.1237905
• Publication Date: 2013-07-05T04:24:48Z
• Authors: Ryan Lister; Eran A. Mukamel; Joseph R. Nery; Mark Urich; Clare A. Puddifoot; Nicholas D. Johnson; Jacinta Lucero; Yun Huang; Andrew J. Dwork; Matthew D. Schultz; Miao Yu; Julian Tonti-Fili...; Holger Heyn; Shijun Hu; Joseph C. Wu; Anjana Rao; Manel Esteller; Chuan He; Fatemeh G. Haghighi; Terrence J. Sejno...; M. Margarita Behrens; Joseph R. Ecker
• Keywords: Epigenomics; Epigenesis; Brain Development

Epigenetic Brainscape modifications and their potential changes during development are of high interest, but few studies have characterized such differences. Lister et al. ( 1237905 , published online 4 July; see the Perspective by Gabel Greenberg ) report whole-genome base-resolution analysis DNA cytosine transcriptome in frontal cortex human mouse brains at multiple developmental stages. The high-resolution mapping methylation (5mC) one its oxidation derivatives (5hmC) key stages provides a comprehensive resource covering temporal dynamics these epigenetic neurons compared to glia. data suggest that marks dynamic brain both humans mice.