A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

• DOI: 10.1126/science.1240925
• Publication Date: 2013-08-02T05:07:22Z
• Authors: Susan Carpenter; Daniel Aiello; Maninjay K. Atianand; Emiliano P. Ricci; Pallavi Gandhi; Lisa L. Hall; Meg Byron; Brian Monks; Meabh Henry-Bezy; Jeanne B. Lawrence; Luke A. J. O’Neill; Melissa J. Moore; Daniel R. Caffrey; Katherine A. Fitz...
• Keywords: Transcriptional Activation; 0301 basic medicine; 570; Transcription, Genetic; *Gene Expression Regulation; Immunology; 610; Heterogeneous-Nuclear Ribonucleoproteins; Cell Line; Molecular Genetics; Mice; 03 medical and health sciences; Cytosol; Genetic; Models; Inflammation & Infection; 616; Immunology, Inflammation & Infection; Innate; Animals; Immunology and Infectious Disease; Cell Nucleus; Inflammation; Macrophages; Toll-Like Receptors; Immunity; Models, Immunological; Macrophage Activation; Immunity, Innate; 3. Good health; Immunological; Gene Expression Regulation; Cyclooxygenase 2; Immune System; RNA; Cytokines; Long Noncoding; RNA Interference; RNA, Long Noncoding; Transcription; Transcription Factors

A New Linc in Innate Immunity Long noncoding RNAs (lncRNAs) have recently emerged as important regulators of gene expression a wide variety biological processes, although specific roles for these molecules the immune system not been described. Carpenter et al. (p. 789 , published online 1 August) now define function one such lncRNA system, lincRNA-Cox2. Whole-transcriptome profiling revealed that lincRNA-Cox2 was induced mouse macrophages response to activation Toll-like receptors—molecules detect microbes and alert respond. LincRNA-Cox2 both positively negatively regulated distinct groups inflammatory genes. Negative regulation mediated by lincRNA-Cox interaction with heterogeneous nuclear ribonucleoprotein A/B A2/B1.