Defining an essential transcription factor program for naïve pluripotency

Pluripotent Stem Cells 0301 basic medicine Mice 03 medical and health sciences Gene Expression Regulation Cell Culture Techniques Animals Computational Biology Gene Regulatory Networks Embryonic Stem Cells Transcription Factors
DOI: 10.1126/science.1248882 Publication Date: 2014-06-05T18:25:59Z
ABSTRACT
Predicting stem cell renewal or differentiation Predicting complex mammalian cell behavior is extremely challenging. Dunn et al. developed a computational model that predicts when embryonic stem cells will self-renew or differentiate. The model revealed an essential program governing pluripotency and identifies a minimal set of components and interactions that accurately predict responses to genetic perturbation. Science , this issue p. 1156
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