Defining an essential transcription factor program for naïve pluripotency
Pluripotent Stem Cells
0301 basic medicine
Mice
03 medical and health sciences
Gene Expression Regulation
Cell Culture Techniques
Animals
Computational Biology
Gene Regulatory Networks
Embryonic Stem Cells
Transcription Factors
DOI:
10.1126/science.1248882
Publication Date:
2014-06-05T18:25:59Z
AUTHORS (5)
ABSTRACT
Predicting stem cell renewal or differentiation
Predicting complex mammalian cell behavior is extremely challenging. Dunn
et al.
developed a computational model that predicts when embryonic stem cells will self-renew or differentiate. The model revealed an essential program governing pluripotency and identifies a minimal set of components and interactions that accurately predict responses to genetic perturbation.
Science
, this issue p.
1156
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