Defining an essential transcription factor program for naïve pluripotency

• DOI: 10.1126/science.1248882
• Publication Date: 2014-06-05T18:25:59Z
• Authors: S.-J. Dunn; G. Martello; B. Yordanov; S. Emmott; A. G. Smith
• Keywords: Pluripotent Stem Cells; 0301 basic medicine; Mice; 03 medical and health sciences; Gene Expression Regulation; Cell Culture Techniques; Animals; Computational Biology; Gene Regulatory Networks; Embryonic Stem Cells; Transcription Factors

Predicting stem cell renewal or differentiation

Predicting complex mammalian cell behavior is extremely challenging. Dunn et al. developed a computational model that predicts when embryonic stem cells will self-renew or differentiate. The model revealed an essential program governing pluripotency and identifies a minimal set of components and interactions that accurately predict responses to genetic perturbation.

Science , this issue p. 1156