Correlated gene expression supports synchronous activity in brain networks

• DOI: 10.1126/science.1255905
• Publication Date: 2015-06-11T18:57:00Z
• Authors: Jonas Richiardi; Andre Altmann; Anna-Clare Milazzo; Catie Chang; M. Mallar Chakrav...; Tobias Banaschewski; Gareth J. Barker; Arun L.W. Bokde; Uli Bromberg; Christian Büchel; Patricia Conrod; Mira Fauth-Bühler; Herta Flor; Vincent Frouin; Jürgen Gallinat; Hugh Garavan; Penny Gowland; Andreas Heinz; Hervé Lemaître; Karl F. Mann; Jean-Luc Martinot; Frauke Nees; Tomáš Paus; Zdenka Pausova; Marcella Rietschel; Trevor W. Robbins; Michael N. Smolka; Rainer Spanagel; Andreas Ströhle; Gunter Schumann; Mike Hawrylycz; Jean-Baptiste Poline; Michael D. Greicius; ; Lisa Albrecht; Chris Andrew; Mercedes Arroyo; Eric Artiges; Semiha Aydin; Christine Bach; Tobias Banaschewski; Alexis Barbot; Gareth Barker; Nathalie Boddaert; Arun Bokde; Zuleima Bricaud; Uli Bromberg; Ruediger Bruehl; Christian Büchel; Arnaud Cachia; Anna Cattrell; Patricia Conrod; Patrick Constant; Jeffrey Dalley; Benjamin Decideur; Sylvane Desrivieres; Tahmine Fadai; Herta Flor; Vincent Frouin; Jürgen Gallinat; Hugh Garavan; Fanny Gollier Briand; Penny Gowland; Bert Heinrichs; Andreas Heinz; Nadja Heym; Thomas Hübner; James Ireland; Bernd Ittermann; Tianye Jia; Mark Lathrop; Dirk Lanzerath; Claire Lawrence; Hervé Lemaitre; Katharina Lüdemann; Christine Macare; Catherine Mallik; Jean-François Mangin; Karl Mann; Jean- Luc Martinot; Eva Mennigen; Fabiana Mesquita ...; Xavier Mignon; Ruben Miranda; Kathrin Müller; Frauke Nees; Charlotte Nymberg; Marie-Laure Paillere; Tomas Paus; Zdenka Pausova; Jean-Baptiste Poline; Luise Poustka; Michael Rapp; Gabriel Robert; Jan Reuter; Marcella Rietschel; Stephan Ripke; Trevor Robbins; Sarah Rodehacke; John Rogers; Alexander Romanowski; Barbara Ruggeri; Christine Schmäl; Dirk Schmidt; Sophia Schneider; MarkGunter Schumann; Florian Schubert; Yannick Schwartz; Michael Smolka; Wolfgang Sommer; Rainer Spanagel; Claudia Speiser; Tade Spranger; Alicia Stedman; Sabina Steiner; Dai Stephens; Nicole Strache; Andreas Ströhle; Maren Struve; Naresh Subramaniam; Lauren Topper; Robert Whelan; Steve Williams; Juliana Yacubian; Monica Zilbovicius; C Peng Wong; Steven Lubbe; Lourdes Martinez-...; Alinda Fernandes; Amir Tahmasebi
• Keywords: 0301 basic medicine; Functional connectivity; 03 medical and health sciences; 610; Gene expression; Genomics; info:eu-repo/classification/ddc/616.8; Systems biology; ddc:616.8

Cooperating brain regions express similar genesWhen the brain is at rest, a number of distinct areas are functionally connected. They tend to be organized in networks. Richiardiet al.compared brain imaging and gene expression data to build computational models of these networks. These functional networks are underpinned by the correlated expression of a core set of 161 genes. In this set, genes coding for ion channels and other synaptic functions such as neurotransmitter release dominate.Science, this issue p.1241