Specific Acceptance of Cardiac Allograft After Treatment with Antibodies to ICAM-1 and LFA-1

• DOI: 10.1126/science.1347662
• Publication Date: 2006-10-05T23:03:06Z
• Authors: Mitsuaki Isobe; Hideo Yagita; Ko Okumura; Akira Ihara
• Keywords: Cytotoxicity, Immunologic; Immunosuppression Therapy; Immunity, Cellular; Graft Survival; Antibodies, Monoclonal; Mice, Inbred Strains; Skin Transplantation; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Rats; 3. Good health; Mice; 03 medical and health sciences; 0302 clinical medicine; Animals; Heart Transplantation; Cell Adhesion Molecules; Spleen

An indefinite survival of cardiac allografts between fully incompatible mice strains was observed when monoclonal antibodies (MAbs) to intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antigen-1 (LFA-1) were simultaneously administered after the transplantation for 6 days. Mice with long-term surviving cardiac allografts accepted skin grafts from the donor-strain but rejected skin grafts from a third-party strain. Because MAbs to ICAM-1 or LFA-1 alone were insufficient for prolonged tolerance, the two MAbs probably acted synergistically to induce specific unresponsiveness. Thus, ICAM-1—LFA-1 adhesion participates in the induction of allograft rejection and MAbs may be useful as therapeutic agents.