Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice

• DOI: 10.1126/science.1361685
• Publication Date: 2006-10-05T23:03:06Z
• Authors: Seth G. N. Grant; Thomas J. O'Dell; Kevin A. Karl; Paul L. Stein; Philippe Soriano; Eric R. Kandel
• Keywords: FYN; LTP induction

Mice with mutations in four nonreceptor tyrosine kinase genes, fyn , src yes and abl were used to study the role of these kinases long-term potentiation (LTP) relation LTP spatial learning memory. All expressed hippocampus. Mutations did not interfere either induction or maintenance LTP. However, mutants, was blunted even though synaptic transmission two short-term forms plasticity, paired-pulse facilitation post-tetanic potentiation, normal. In parallel blunting LTP, mutants showed impaired learning, consistent a functional link between learning. Although is at mature synapses, its lack expression during development resulted an increased number granule cells dentate gyrus pyramidal CA3 region. Thus, common pathway may regulate growth neurons developing hippocampus strength plasticity