Galactose Oxidation in the Design of Immunogenic Vaccines

• DOI: 10.1126/science.1598588
• Publication Date: 2006-10-05T23:03:06Z
• Authors: Biao Zheng; Sara J. Brett; John P. Tite; M. Robert Lifely; Thomas A. Brodie; John Rhodes
• Keywords: Cytotoxicity, Immunologic; 0301 basic medicine; T-Lymphocytes; Vaccination; Galactose; Neuraminidase; HIV Envelope Protein gp120; Lymphocyte Activation; Galactose Oxidase; 3. Good health; Mice; 03 medical and health sciences; 0302 clinical medicine; Adjuvants, Immunologic; Antibody Formation; Animals; Peptides; Oxidation-Reduction

Potent immunological adjuvants are urgently required to complement recombinant and synthetic vaccines. However, it has not been possible derive new principles for the design of vaccine from knowledge mechanism immunogenicity. Carbonyl-amino condensations, which essential inductive interaction between antigen-presenting cells T helper cells, were tested as a target enhancement immune responses. Enzymic oxidation cell-surface galactose increase aminereactive carbonyl groups on murine lymphocytes provided potent, noninflammatory method enhancing immunogenicity viral, bacterial, protozoal subunit vaccines in mice.