Selective Activation of the B Natriuretic Peptide Receptor by C-Type Natriuretic Peptide (CNP)

• DOI: 10.1126/science.1672777
• Publication Date: 2006-10-05T22:10:16Z
• Authors: Kerry J. Koller; David G. Lowe; Gregory L. Bennett; Naoto Minamino; Kenji Kangawa; Hisayuki Matsuo; David V. Goeddel
• Keywords: NPR2; NPR1; Atrial natriuretic peptide

The natriuretic peptides are hormones that can stimulate natriuretic, diuretic, and vasorelaxant activity in vivo, presumably through the activation of two known cell surface receptor guanylyl cyclases (ANPR-A ANPR-B). Although atrial peptide (ANP) and, to a lesser extent, brain (BNP) efficient activators ANPR-A cyclase, neither hormone significantly ANPR-B. A member this family, C-type (CNP), potently selectively activated human ANPR-B cyclase. CNP does not increase guanosine 3',5'-monophosphate accumulation cells expressing ANPR-A. affinity for is 50- or 500-fold higher than ANP BNP, respectively. This ligand-receptor pair may be involved regulation fluid homeostasis by central nervous system.