Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia

• DOI: 10.1126/science.1676542
• Publication Date: 2006-10-05T22:10:16Z
• Authors: Masahiko Hatano; Charles W. M. Rob...; Mark Minden; William M. Crist; Stanley J. Korsmeyer
• Keywords: HNF1B; Homeobox protein Nkx-2.5; Homeobox A1; EMX2

Molecular cloning of the t(10;14)(q24;q11) recurrent breakpoint T cell acute lymphoblastic leukemia has demonstrated a transcript for candidate gene TCL3. Characterization this from chromosome segment 10q24 revealed it to be new homeobox, HOX11. The HOX11 homeodomain is most similar that murine Hlx and possesses markedly glycine-rich variable region an acidic carboxyl terminus. HOX11, while expressed in liver, was not detected normal thymus or cells. This lineage-restricted homeobox deregulated upon translocation into receptor locus where may act as oncogene.