Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

• DOI: 10.1126/science.1715095
• Publication Date: 2006-10-05T22:10:16Z
• Authors: Hilmar Bading; Michael E. Greenberg
• Keywords: Long-term depression

The N -methyl-D-aspartate (NMDA) receptor, a subtype of glutamate receptors, plays key role in synaptic plasticity the nervous system. After NMDA receptor activation, calcium entry into postsynaptic neuron is critical initial event. However, subsequent mechanisms by which signal processed are incompletely understood. Stimulation cultured rat hippocampal cells with resulted rapid and transient tyrosine phosphorylation 39-kilodalton protein (p39). Tyrosine p39 was triggered required an influx Ca 2+ from extracellular medium. Because found to be highly related or identical microtubule-associated 2 kinase, may sequential activation kinases.