Regulation of Rransendothelial Neutrophil Migration by Endogenous Interleukin-8

• DOI: 10.1126/science.1718038
• Publication Date: 2006-10-05T22:10:16Z
• Authors: Andreas R. Huber; Steven L. Kunkel; Robert F. Todd; Stephen J. Weiss
• Keywords: Proinflammatory cytokine; Interleukin 8

Movement of neutrophils from the bloodstream to inflamed tissue depends on activation both neutrophil and endothelial cell. Endothelial cells lining postcapillary venule respond proinflammatory mediators by expressing adhesion molecules synthesizing a variety neutrophil-activating factors. cell production 77-amino acid variant interleukin-8 (IL-8) was found be requirement for invasion through vessel wall model. IL-8 secreted cytokine- or lipopolysaccharide-stimulated induced rapid shedding lectin molecule-1, up-regulation leukocyte β 2 integrins, attachment transmigration neutrophils. Thus, endogenous regulates transvenular traffic during acute inflammatory responses.