A Retroviral Oncogene, akt , Encoding a Serine-Threonine Kinase Containing an SH2-Like Region

• DOI: 10.1126/science.1833819
• Publication Date: 2006-10-05T22:10:16Z
• Authors: Alfonso Bellacosa; Joseph R. Testa; Stephen P. Staal; Philip N. Tsichlis
• Keywords: AKT3; AKT2; c-Raf; MAP2K7; Phosphoprotein

The v- akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence analysis of and biochemical characterization product revealed that it protein kinase C-related serine-threonine whose cellular homolog is expressed in most tissues, with the highest amount found thymus. Although Akt kinase, part regulatory region similar to Src homology-2 domain, structural motif characteristic cytoplasmic tyrosine kinases functions protein-protein interactions. This suggests may form functional link between phosphorylation pathways.