Establishment of the Mesoderm-Neuroectoderm Boundary in the Drosophila Embryo

• DOI: 10.1126/science.1925551
• Publication Date: 2006-10-05T22:10:16Z
• Authors: David Kosman; Y. Tony Ip; Michael Levine; Kavita Arora
• Keywords: Neuroectoderm; Body plan

A gradient of the maternal morphogen dorsal establishes asymmetric patterns gene expression along dorsal-ventral axis early embryos and activates regulatory genes twist snail , which are responsible for differentiation ventral mesoderm. Expression is restricted to presumptive mesoderm, sharp lateral limits this help define mesoderm-neuroectoderm boundary by repressing that neuroectoderm. The encodes a zinc finger protein, neuroectodermal normally ventral-lateral regions expressed throughout - mutants. formation border involves dosage-sensitive interactions between encode proteins related mammalian transcription factors NF-kB MyoD, respectively.