D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons

• DOI: 10.1126/science.2147780
• Publication Date: 2006-10-05T22:10:14Z
• Authors: Charles R. Gerfen; Thomas M. Engber; Lawrence C. Mahan; Zvi Susel; Thomas N. Chase; Frederick J. Monsma; David R. Sibley
• Keywords: Quinpirole; Nigrostriatal pathway; Pars reticulata; Putamen

The striatum, which is the major component of basal ganglia in brain, regulated part by dopaminergic input from substantia nigra. Severe movement disorders result loss striatal dopamine patients with Parkinson's disease. Rats lesions nigrostriatal pathway caused 6-hydroxydopamine (6-OHDA) serve as a model for disease and show alterations gene expression two output systems striatum to globus pallidus Striatopallidal neurons 6-OHDA-induced elevation their specific messenger RNAs (mRNAs) encoding D 2 receptor enkephalin, reversed subsequent continuous treatment agonist quinpirole. Conversely, striatonigral reduction mRNAs 1 substance P, daily injections SKF-38393. This also increases dynorphin mRNA neurons. Thus, differential effects on striatopallidal are mediated subtypes, respectively.