The Cholinergic Neuronal Differentiation Factor from Heart Cells Is Identical to Leukemia Inhibitory Factor

• DOI: 10.1126/science.2512641
• Publication Date: 2006-10-05T21:21:28Z
• Authors: Tetsuo Yamamori; Keiko Fukada; Ruedi Aebersold; Sigrun Korsching; Ming-Ji Fann; Paul H. Patterson
• Keywords: 0301 basic medicine; Molecular Sequence Data; 610; Leukemia Inhibitory Factor; Choline; Mice; 03 medical and health sciences; Sequence Homology, Nucleic Acid; 616; Animals; Humans; Amino Acid Sequence; Cloning, Molecular; Cells, Cultured; Immunosorbent Techniques; Neurons; Lymphokines; Base Sequence; Interleukin-6; Myocardium; Cell Differentiation; DNA; Growth Inhibitors; Rats; 3. Good health

A protein secreted by cultured rat heart cells can direct the choice of neurotransmitter phenotype made sympathetic neurons. Structural analysis and biological assays demonstrated that this is identical to a regulates growth differentiation embryonic stem myeloid cells, stimulates bone remodeling acute-phase synthesis in hepatocytes. This has been termed D factor, DIA, DIF, DRF, HSFIII, LIF. Thus, cytokine, like IL-6 TGFβ, embryo adult many tissues, now including nervous system.