Chromosomal Rearrangement Generating a Composite Gene for a Developmental Transcription Factor

• DOI: 10.1126/science.2536191
• Publication Date: 2006-10-05T21:21:28Z
• Authors: Patrick Stragier; Barbara Kunkel; Lee Kroos; Richard Losick
• Keywords: Sigma factor; Transcription

Differential gene expression in the mother cell chamber of sporulating cells Bacillus subtilis is determined part by an RNA polymerase sigma factor called σ K (or 27 ). The was assigned as product sporulation spoIVCB on basis partial amino-terminal amino acid sequence purified protein. now shown to be a truncated capable specifying only terminal half . carboxyl specified another gene, spoIIIC , which becomes joined inframe at intermediate stage site-specific recombination within 5-base pair repeated sequence. Juxtaposition and need not reversible that its chromosome are discarded end developmental cycle. rearrangement chromosomal DNA could account for presence selectively may precedent generation type-specific regulatory proteins other systems where undergo differentiation.