Defining protective responses to pathogens: cytokine profiles in leprosy lesions
0301 basic medicine
Base Sequence
Molecular Sequence Data
Polymerase Chain Reaction
Immunity, Innate
Interleukin-10
3. Good health
Interferon-gamma
03 medical and health sciences
Leprosy
Cytokines
Humans
Interleukin-2
Interleukin-4
RNA, Messenger
Interleukin-5
Skin
DOI:
10.1126/science.254.5029.277
Publication Date:
2021-06-24T03:20:45Z
AUTHORS (7)
ABSTRACT
The immunological mechanisms required to engender resistance have been defined in few infectious diseases of man, and the role of specific cytokines is unclear. Leprosy presents clinically as a spectrum in which resistance correlates with cell-mediated immunity to the pathogen. To assess in situ cytokine patterns, messenger RNA extracted from leprosy skin biopsy specimens was amplified by the polymerase chain reaction with 14 cytokine-specific primers. In lesions of the resistant form of the disease, messenger RNAs coding for interleukin-2 and interferon-gamma were most evident. In contrast, messenger RNAs for interleukin-4, interleukin-5, and interleukin-10 predominated in the multibacillary form. Thus, resistance and susceptibility were correlated with distinct patterns of cytokine production.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (17)
CITATIONS (159)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....