A Formalin-Inactivated Whole SIV Vaccine Confers Protection in Macaques

• DOI: 10.1126/science.2555923
• Publication Date: 2006-10-05T21:21:28Z
• Authors: Michael Murphey-Corb; Louis N. Martin; Billie Davison-Fa...; Ronald C. Montelaro; Mark Miller; Melanie West; Susumu Ohkawa; Gary B. Baskin; Jing-Yu Zhang; Scott D. Putney; Anthony C. Allison; Deborah A. Eppstein
• Keywords: Simian immunodeficiency virus; Muramyl dipeptide; Rhesus macaque

A vaccine against human immunodeficiency virus (HIV) would be highly effective in stopping the acquired syndrome (AIDS) epidemic. comprehensive evaluation of potential methodologies can made by means simian model for AIDS, which takes advantage similarities viral composition and disease between (SIV) infection rhesus macaques HIV humans. Immunization with a formalin-inactivated whole SIV potentiated either alum Syntex adjuvant threonyl muramyl dipeptide (MDP) or MDP alone resulted protection eight nine monkeys challenged ten animal-infectious doses pathogenic virus. These results demonstrate that is inducing immune responses protect lentivirus AIDS-like disease.