Central Hypotensive Effects of the α 2a -Adrenergic Receptor Subtype

• DOI: 10.1126/science.273.5276.801
• Publication Date: 2006-10-27T18:30:41Z
• Authors: Leigh B. MacMillan; Lutz Hein; Marta S. Smith; Michael T. Piascik; Lee E. Limbird
• Keywords: Imidazoline receptor

α 2 -Adrenergic receptors (α ARs) present in the brainstem decrease blood pressure and are targets for clinically effective antihypertensive drugs. The existence of three AR subtypes, lack subtype-specific ligands, cross-reactivity agonists with imidazoline has precluded an understanding role individual subtypes hypotensive response. Gene targeting was used to introduce a point mutation into 2a subtype mouse genome. response lost mutant mice, demonstrating that plays principal this