Neurogenic Amplification of Immune Complex Inflammation

• DOI: 10.1126/science.273.5282.1722
• Publication Date: 2006-10-27T18:30:41Z
• Authors: Carmen R. Bozic; Bao Lu; Uta E. Höpken; Craig Gerard; Norma P. Gerard
• Keywords: Immune complex; Anaphylatoxin

The formation of intrapulmonary immune complexes in mice generates a vigorous inflammatory response characterized by microvascular permeability and polymorphonuclear neutrophil influx. Gene-targeted disruption the substance P receptor (NK-1R) protected lung from complex injury, as did C5a anaphylatoxin receptor. Immunoreactive was measurable fluids lining at time points before influx may thus be involved an early step to lung.