Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

• DOI: 10.1126/science.273.5283.1856
• Publication Date: 2006-10-27T18:30:41Z
• Authors: Michael Dean; Mary Carrington; Cheryl Winkler; Gavin A. Huttley; Michael W. Smith; Rando Allikmets; James J. Goedert; Susan P. Buchbinder; Eric Vittinghoff; Edward Gomperts; Sharyne Donfield; David Vlahov; Richard Kaslow; Alfred Saah; Charles Rinaldo; Roger Detels; Stephen J. O'Brien
• Keywords: Heterozygote advantage; Chemokine receptor CCR5

The chemokine receptor 5 (CKR5) protein serves as a secondary on CD4 + T lymphocytes for certain strains of human immunodeficiency virus-type 1 (HIV-1). CKR5 structural gene was mapped to chromosome 3p21, and 32-base pair deletion allele ( CKR5Δ32 ) identified that is present at frequency ∼0.10 in the Caucasian population United States. An examination 1955 patients included among six well-characterized acquired syndrome (AIDS) cohort studies revealed 17 homozygotes occurred exclusively 612 exposed HIV-1 antibody-negative individuals (2.8 percent) not all 1343 HIV-1-infected individuals. heterozygotes significantly elevated groups had survived infection more than 10 years, and, some risk groups, twice frequent their occurrence rapid progressors AIDS. Survival analysis clearly shows disease progression slower homozygous normal gene. may act recessive restriction against exert dominant phenotype delaying AIDS infected