Peptide Binding and Release by Proteins Implicated as Catalysts of Protein Assembly

• DOI: 10.1126/science.2756425
• Publication Date: 2006-10-05T21:21:28Z
• Authors: Gregory C. Flynn; Thomas G. Chappell; James E. Rothman
• Keywords: Adenosine triphosphate

Two members of the hsp70 family, termed hsc70 and BiP, have been implicated in promoting protein folding assembly processes cytoplasm lumen endoplasmic reticulum, respectively. Short hydrophilic (8 to 25 residues) synthetic peptides now tested as possible mimics polypeptide chain substrates help define an enzymatic basis for these activities. Both BiP specific peptide binding sites. Peptide elicits hydrolysis adenosine triphosphate, with subsequent release bound peptide.