Imaging of Memory-Specific Changes in the Distribution of Protein Kinase C in the Hippocampus

• DOI: 10.1126/science.2772638
• Publication Date: 2006-10-05T21:21:28Z
• Authors: James L. Olds; Matthew L. Anderson; Donna L. McPhie; Latonia D. Staten; Daniel L. Alkon
• Keywords: 0301 basic medicine; 03 medical and health sciences; Memory; Animals; Autoradiography; Rabbits; Hippocampus; Phorbol 12,13-Dibutyrate; Protein Kinase C

Activation of protein kinase C (PKC) can mimic the biophysical effects associative learning on neurons. Furthermore, classical conditioning rabbit nictitating membrane (a form learning) produces translocation PKC activity from cytosolic to compartments CA1 region hippocampus. Evidence is provided here for a significant change in amount and distribution within cell field hippocampus that specific learning. This seen at 1 day after as focal increments [ 3 H]phorbol-12,13-dibutyrate binding computer-generated images produced coronal autoradiographs brain. In addition, days learning, suggest redistribution soma dendrites.