Vigorous HIV-1-Specific CD4 + T Cell Responses Associated with Control of Viremia

• DOI: 10.1126/science.278.5342.1447
• Publication Date: 2002-07-27T09:37:20Z
• Authors: Eric S. Rosenberg; James M. Billingsley; Angela M. Caliendo; Steven L. Boswell; Paul E. Sax; Spyros A. Kalams; Bruce D. Walker
• Keywords: Viremia; Polyclonal antibodies

Virus-specific CD4 + T helper lymphocytes are critical to the maintenance of effective immunity in a number chronic viral infections, but characteristically undetectable human immunodeficiency virus–type 1 (HIV-1) infection. In individuals who control viremia absence antiviral therapy, polyclonal, persistent, and vigorous HIV-1–specific cell proliferative responses were present, resulting elaboration interferon-γ β chemokines. persons with infection, p24 inversely related load. Strong also detected following treatment acutely infected potent therapy. The cells likely be important immunotherapeutic interventions vaccine development.