Hyaluronan Synthase of Chlorella Virus PBCV-1
Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
0301 basic medicine
570
Genes, Viral
Molecular Sequence Data
Glycosyltransferases
Membrane Proteins
Chlorella
Plant Pathology
Xenopus Proteins
540
Uridine Diphosphate Glucose Dehydrogenase
Recombinant Proteins
Substrate Specificity
3. Good health
03 medical and health sciences
Transferases
Phycodnaviridae
Amino Acid Sequence
Glucuronosyltransferase
Hyaluronic Acid
Hyaluronan Synthases
Sequence Alignment
DOI:
10.1126/science.278.5344.1800
Publication Date:
2002-07-27T09:35:26Z
AUTHORS (5)
ABSTRACT
Sequence analysis of the 330-kilobase genome virus PBCV-1 that infects a chlorella-like green algae revealed an open reading frame, A98R, with similarity to several hyaluronan synthases. Hyaluronan is essential polysaccharide found in higher animals as well few pathogenic bacteria. Expression A98R gene product Escherichia coli indicated recombinant protein authentic synthase. expressed early infection and produced infected algae. These results demonstrate can encode enzyme capable synthesizing carbohydrate polymer exists outside their pathogens.
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CITATIONS (113)
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