Hyaluronan Synthase of Chlorella Virus PBCV-1

Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) 0301 basic medicine 570 Genes, Viral Molecular Sequence Data Glycosyltransferases Membrane Proteins Chlorella Plant Pathology Xenopus Proteins 540 Uridine Diphosphate Glucose Dehydrogenase Recombinant Proteins Substrate Specificity 3. Good health 03 medical and health sciences Transferases Phycodnaviridae Amino Acid Sequence Glucuronosyltransferase Hyaluronic Acid Hyaluronan Synthases Sequence Alignment
DOI: 10.1126/science.278.5344.1800 Publication Date: 2002-07-27T09:35:26Z
ABSTRACT
Sequence analysis of the 330-kilobase genome virus PBCV-1 that infects a chlorella-like green algae revealed an open reading frame, A98R, with similarity to several hyaluronan synthases. Hyaluronan is essential polysaccharide found in higher animals as well few pathogenic bacteria. Expression A98R gene product Escherichia coli indicated recombinant protein authentic synthase. expressed early infection and produced infected algae. These results demonstrate can encode enzyme capable synthesizing carbohydrate polymer exists outside their pathogens.
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