The Gene for Enhancer Binding Proteins E12/E47 Lies at the t(1;19) Breakpoint in Acute Leukemias

• DOI: 10.1126/science.2799390
• Publication Date: 2006-10-05T21:21:28Z
• Authors: Julia D. Mellentin; Cornelis Murre; Timothy A. Donlon; Patrick S. McCaw; Stephen D. Smith; Andrew J. Carroll; Marcy E. McDonald; David Baltimore; Michael L. Cleary
• Keywords: Breakpoint; Southern blot; Transcription

The gene ( E2A ) that codes for proteins with the properties of immunoglobulin enhancer binding factors E12/E47 was mapped to chromosome region 19p13.2-p13.3, a site associated nonrandom translocations in acute lymphoblastic leukemias. majority t(1;19)(q23;p13)-carrying leukemias and cell lines studied contained rearrangements as determined by DNA blot analyses. altered transcriptional unit, resulting synthesis transcript larger than normal-sized mRNAs one this translocation. These observations indicate transcription factor is located at breakpoint consistently recurring chromosomal translocation many suggest direct role alteration such pathogenesis some malignancies.