Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

• DOI: 10.1126/science.283.5400.390
• Publication Date: 2002-07-27T09:40:50Z
• Authors: Harumi Suzuki; Yasuo Terauchi; Mari Fujiwara; Shinichi Aizawa; Yoshio Yazaki; Takashi Kadowaki; Shigeo Koyasu
• Keywords: Phosphoinositide 3-kinase

Mice with a targeted gene disruption of p85α, regulatory subunit phosphoinositide 3-kinase, had impaired B cell development at the pro–B stage, reduced numbers mature cells and peritoneal CD5 + Ly-1 cells, proliferative responses, no T cell–independent antibody production. These phenotypes are nearly identical to those Btk −/− or xid (X-linked immunodeficiency) mice. results provide evidence that p85α is functionally linked pathway in antigen receptor–mediated signal transduction pivotal functions.