Central Role for the Lens in Cave Fish Eye Degeneration
Embryonic Induction
Homeodomain Proteins
0301 basic medicine
Rhodopsin
0303 health sciences
PAX6 Transcription Factor
Tumor Suppressor Proteins
Fishes
Apoptosis
Cell Differentiation
Eye
Biological Evolution
Retina
DNA-Binding Proteins
Repressor Proteins
03 medical and health sciences
Proliferating Cell Nuclear Antigen
Lens, Crystalline
In Situ Nick-End Labeling
Animals
Paired Box Transcription Factors
Eye Proteins
DOI:
10.1126/science.289.5479.631
Publication Date:
2002-07-27T09:40:21Z
AUTHORS (2)
ABSTRACT
Astyanax mexicanus
is a teleost with eyed surface-dwelling and eyeless cave-dwelling forms. Eye formation is initiated in cave fish embryos, but the eye subsequently arrests and degenerates. The surface fish lens stimulates growth and development after transplantation into the cave fish optic cup, restoring optic tissues lost during cave fish evolution. Conversely, eye growth and development are retarded following transplantation of a surface fish lens into a cave fish optic cup or lens extirpation. These results show that evolutionary changes in an inductive signal from the lens are involved in cave fish eye degeneration.
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