Central Role for the Lens in Cave Fish Eye Degeneration

Embryonic Induction Homeodomain Proteins 0301 basic medicine Rhodopsin 0303 health sciences PAX6 Transcription Factor Tumor Suppressor Proteins Fishes Apoptosis Cell Differentiation Eye Biological Evolution Retina DNA-Binding Proteins Repressor Proteins 03 medical and health sciences Proliferating Cell Nuclear Antigen Lens, Crystalline In Situ Nick-End Labeling Animals Paired Box Transcription Factors Eye Proteins
DOI: 10.1126/science.289.5479.631 Publication Date: 2002-07-27T09:40:21Z
ABSTRACT
Astyanax mexicanus is a teleost with eyed surface-dwelling and eyeless cave-dwelling forms. Eye formation is initiated in cave fish embryos, but the eye subsequently arrests and degenerates. The surface fish lens stimulates growth and development after transplantation into the cave fish optic cup, restoring optic tissues lost during cave fish evolution. Conversely, eye growth and development are retarded following transplantation of a surface fish lens into a cave fish optic cup or lens extirpation. These results show that evolutionary changes in an inductive signal from the lens are involved in cave fish eye degeneration.
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